Zhi-Hao Wang Selected Research

asparaginylendopeptidase (legumain)

1/2021	Delta- and beta- secretases crosstalk amplifies the amyloidogenic pathway in Alzheimer's disease.
1/2021	Optimized TrkB Agonist Ameliorates Alzheimer's Disease Pathologies and Improves Cognitive Functions via Inhibiting Delta-Secretase.
1/2021	A delta-secretase-truncated APP fragment activates CEBPB, mediating Alzheimer's disease pathologies.
1/2021	TrkB receptor cleavage by delta-secretase abolishes its phosphorylation of APP, aggravating Alzheimer's disease pathologies.
1/2020	Traumatic brain injury triggers APP and Tau cleavage by delta-secretase, mediating Alzheimer's disease pathology.
11/2019	Author Correction: C/EBPβ regulates delta-secretase expression and mediates pathogenesis in mouse models of Alzheimer's disease.
1/2019	Delta-secretase-cleaved Tau antagonizes TrkB neurotrophic signalings, mediating Alzheimer's disease pathologies.
12/2018	Delta-secretase (AEP) mediates tau-splicing imbalance and accelerates cognitive decline in tauopathies.
1/2018	BDNF inhibits neurodegenerative disease-associated asparaginyl endopeptidase activity via phosphorylation by AKT.
1/2018	C/EBPβ regulates delta-secretase expression and mediates pathogenesis in mouse models of Alzheimer's disease.

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Zhi-Hao Wang Research Topics

Disease

21	Alzheimer Disease (Alzheimer's Disease) 08/2022 - 01/2014
14	Cognitive Dysfunction 08/2022 - 01/2017
12	Insulin Resistance 08/2022 - 02/2010
8	Fibrosis (Cirrhosis) 01/2022 - 01/2016
7	Inflammation (Inflammations) 03/2022 - 02/2010
7	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2021 - 02/2013
5	Amyloid Plaque 01/2022 - 01/2018
4	Vascular Remodeling 01/2022 - 12/2015
4	Hypertrophy 08/2021 - 03/2011
4	Memory Disorders (Memory Loss) 01/2018 - 02/2013
4	Metabolic Syndrome (Dysmetabolic Syndrome X) 04/2017 - 02/2010
3	Hypertension (High Blood Pressure) 01/2022 - 01/2008
3	Colorectal Neoplasms (Colorectal Cancer) 01/2022 - 10/2019
3	Neoplasms (Cancer) 01/2022 - 10/2019
3	Atrophy 12/2021 - 01/2020
3	Coronary Artery Disease (Coronary Atherosclerosis) 01/2021 - 07/2015
3	Type 2 Diabetes Mellitus (MODY) 01/2019 - 12/2015
3	Tauopathies 12/2018 - 01/2014
2	Coronary Stenosis (Coronary Artery Stenosis) 01/2022 - 01/2020
2	Motor Disorders 12/2021 - 11/2019
2	Body Weight (Weight, Body) 01/2021 - 03/2011
2	Coronary Disease (Coronary Heart Disease) 01/2021 - 01/2018
2	Heart Failure 01/2021 - 01/2012
2	Hemorrhage 04/2020 - 02/2011
2	Atherosclerosis 01/2020 - 08/2018
2	Carotid Artery Diseases 01/2017 - 06/2010
2	Diabetic Cardiomyopathies 11/2016 - 01/2016
2	Poisoning 09/2014 - 05/2013
1	Postoperative Pain 01/2022
1	Critical Illness (Critically Ill) 01/2022
1	Fatigue 01/2022
1	Autoimmune Diseases of the Nervous System 01/2022
1	Kidney Calculi (Kidney Stone) 01/2022
1	Cardiovascular Diseases (Cardiovascular Disease) 01/2022
1	Sepsis-Associated Encephalopathy 01/2022
1	Constipation 12/2021
1	Macular Degeneration (Age-Related Maculopathy) 01/2021
1	Sarcopenia 01/2021

Drug/Important Bio-Agent (IBA)

11	asparaginylendopeptidase (legumain)IBA 01/2021 - 09/2017
8	Proteins (Proteins, Gene)FDA Link 10/2021 - 02/2010
6	Brain-Derived Neurotrophic Factor (BDNF)IBA 01/2022 - 01/2018
6	Amyloid Precursor Protein Secretases (beta-Secretase)IBA 01/2021 - 01/2019
5	Amyloid (Amyloid Fibrils)IBA 10/2021 - 01/2021
5	CytokinesIBA 01/2021 - 02/2010
4	Biomarkers (Surrogate Marker)IBA 03/2022 - 09/2014
4	Transcription Factors (Transcription Factor)IBA 12/2021 - 01/2018
4	Apolipoproteins E (ApoE)IBA 10/2021 - 12/2017
4	Pharmaceutical PreparationsIBA 01/2021 - 02/2012
3	Apolipoprotein E4IBA 01/2022 - 01/2021
3	Biological ProductsIBA 01/2022 - 01/2020
3	LipidsIBA 08/2021 - 02/2020
3	Histones (Histone)IBA 01/2018 - 01/2017
3	Trimetazidine (Vastarel)IBA 01/2018 - 01/2016
2	Insulin (Novolin)FDA Link 08/2022 - 01/2018
2	prostaglandin F2alpha receptorIBA 01/2022 - 12/2015
2	ApolipoproteinsIBA 10/2021 - 01/2021
2	Glucose (Dextrose)FDA LinkGeneric 08/2021 - 01/2018
2	Peptide Hydrolases (Proteases)FDA Link 01/2021 - 01/2021
2	Microtubule-Associated Proteins (Microtubule-Associated Protein 2)IBA 01/2021 - 01/2015
2	Simendan (Levosimendan)IBA 01/2021 - 04/2020
2	CholesterolIBA 01/2021 - 12/2015
2	Protein Disulfide-IsomerasesIBA 01/2021 - 12/2016
2	CollagenIBA 01/2020 - 12/2015
2	Testosterone (Sustanon)FDA Link 01/2020 - 01/2019
2	SynucleinsIBA 11/2019 - 01/2018
2	Protein Isoforms (Isoforms)IBA 12/2018 - 01/2015
2	Peptides (Polypeptides)IBA 01/2018 - 09/2014
2	ProstaglandinsIBA 10/2016 - 12/2015
2	Carbon MonoxideIBA 09/2014 - 05/2013
1	LipopolysaccharidesIBA 08/2022
1	Phosphocreatine (Neoton)IBA 03/2022
1	Interleukin-6 (Interleukin 6)IBA 03/2022
1	Troponin IIBA 03/2022
1	Analgesics (Analgesic Drugs)IBA 01/2022
1	Sufentanil (Sufenta)FDA LinkGeneric 01/2022
1	GlucocorticoidsIBA 01/2022
1	Plasminogen Activator Inhibitor 1IBA 01/2022
1	Emodin (Archin)IBA 01/2022
1	Matrix Metalloproteinases (MMPs)IBA 01/2022
1	Cisplatin (Platino)FDA LinkGeneric 01/2022
1	Triiodothyronine (Liothyronine)FDA LinkGeneric 01/2022
1	MineralsIBA 01/2022
1	Succinate Dehydrogenase (Fumarate Reductase)IBA 12/2021
1	salicylhydroxamic acid (SHAM)IBA 01/2021
1	factor EF-PIBA 01/2021
1	27-hydroxycholesterolIBA 01/2021
1	High-Temperature Requirement A Serine Peptidase 1IBA 01/2021
1	AsparagineIBA 01/2021
1	Messenger RNA (mRNA)IBA 01/2021
1	SolventsIBA 01/2021
1	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2021
1	trkB ReceptorIBA 01/2021
1	CCAAT-Enhancer-Binding Protein-betaIBA 01/2021
1	Therapeutic UsesIBA 01/2021

Therapy/Procedure

5	Therapeutics 01/2022 - 02/2011
2	Oral Administration 12/2021 - 01/2021
2	Drug Therapy (Chemotherapy) 01/2021 - 10/2019
1	Stents 03/2022
1	Percutaneous Coronary Intervention 03/2022
1	Immunotherapy 01/2021